Best Systemic Enzymes | Reviews & Recommendations

Truly finding the systemic enzymes is only effective if you can get your hands on some options, which is exactly what we did.

After researching many products, we shaved the list down to the top 10 options today by researching design, capability, durability, features, price, and overall build quality.

We researched hours on these products and compared them to one another to see which one is the best for every need. Read this systemic enzymes article with an extensive buying guide if you're interested in buying or learning about these systemic enzymes.

# Preview Product Score
1 Pure Encapsulations Systemic Enzyme Complex | Supplement to Support Muscle, Joint, Cartilage, and Connective Tissue Health* | 180 Capsules

Pure Encapsulations Systemic Enzyme Complex | Supplement to Support Muscle, Joint, Cartilage, and...

9.7
2 Serrapeptase Enzymes | Up to 2 Month Supply | Vegan Serrapeptase High Potency Sinus Relief Pills for Allergy Support, Tissue Health and Cellular Health | Plant Based, Vegan Capsule | Enteric Coated

Serrapeptase Enzymes | Up to 2 Month Supply | Vegan Serrapeptase High Potency Sinus Relief Pills for...

9.6
3 Pro-OneZyme Best Proteolytic Systemic Enzymes Supplement with Nattokinase & Seapose - 90 Capsules

Pro-OneZyme Best Proteolytic Systemic Enzymes Supplement with Nattokinase & Seapose - 90 Capsules

9.4
4 Garden of Life Systemic Enzymes - FYI Restore for Muscle and Tissue Recovery for Women and Men, Vegan Enzyme Supplement, Bromelain, Protease, Papain, Vegan and Gluten Free, 60 Enteric Coated Capsules

Garden of Life Systemic Enzymes - FYI Restore for Muscle and Tissue Recovery for Women and Men,...

9.8
5 Vitälzym Original Proteolytic Systemic Digestive Enzyme Formula Serrapeptase Source | Anti-Inflammatory Immune and Joint Support Increase Blood Flow Cardio Function | Healthy Men Women (90 Capsules)

Vitälzym Original Proteolytic Systemic Digestive Enzyme Formula Serrapeptase Source |...

9.5
6 Vitälzym Proteolytic Systemic Enzymes Liquid Gel Capsules with Serrapeptase, Anti-inflammatory Defense Treatment, Immune and Joint Support, Natural Ache Relief Plus Fertility Supplement (360 Capsules)

Vitälzym Proteolytic Systemic Enzymes Liquid Gel Capsules with Serrapeptase, Anti-inflammatory...

9.6
7 Garden of Life Joint Supplement for Men and Women - Wobenzym N Systemic Enzymes, Clinically Studied Formula for Healthy Joints, Mobility, Flexibility, Post-Exercise Recovery, Gluten Free, 200 Tablets

Garden of Life Joint Supplement for Men and Women - Wobenzym N Systemic Enzymes, Clinically Studied...

9.2
8 Excellacor – Proteolytic Systemic Enzymes Formula – with Enteric-Coated Serrapeptase - Total Body Support - 90 Vegetarian Capsules - AST Enzymes

Excellacor – Proteolytic Systemic Enzymes Formula – with Enteric-Coated Serrapeptase - Total...

9.8
9 HCP Formulas - Fibrenza - Systemic Enzyme Complex with Fibrinolytic & Proteolytic Enzymes - Fibrin Defense, Inflammation & Cardiovascular Support - Vegetarian - Dietary Supplement - 60 Caps

HCP Formulas - Fibrenza - Systemic Enzyme Complex with Fibrinolytic & Proteolytic Enzymes - Fibrin...

9.6
10 Rootcology Systemic Enzymes (60 Capsules)

Rootcology Systemic Enzymes (60 Capsules)

9.2

List of best systemic enzymes  Reviews

Bestseller No. 1

Pure Encapsulations Systemic Enzyme Complex | Supplement to Support Muscle, Joint, Cartilage, and Connective Tissue Health* | 180 Capsules

  • Muscular Health: Systemic Enzyme Complex is formulated to support the overall health of the musculoskeletal system.*
  • Muscle Comfort: Supports a healthy response to temporary muscle soreness and temporary joint discomfort associated with exercise.*
  • Joint & Cartilage Health: Supports healthy connective tissue, as well as joint and cartilage health.*
  • Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
  • Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
Bestseller No. 2

Serrapeptase Enzymes | Up to 2 Month Supply | Vegan Serrapeptase High Potency Sinus Relief Pills for Allergy Support, Tissue Health and Cellular Health | Plant Based, Vegan Capsule | Enteric Coated

  • Serrapeptase Systemic Enzymes: This proprietary blend of enteric-coated Serrapeptase (also known as Serratiopeptidase) and a Protease blend is combined with enzyme enhancing vitamins and minerals to support your overall health. Encapsulated in pine-based vegan capsules, you can easily incorporate these into your routine.
  • Multiple Benefits: Serrapeptase may help to support the body's circulatory system, healthy tissue homeostasis, and the body’s natural inflammation process. This powerful enzyme blend may support cellular, tissue, and systemic health, while promoting healthy immune activity and aiding your body in maintaining normal microbial balance.
  • Advanced Enzyme Complex: 120,000 SPU Serrapeptase in each capsule. Sometimes referred to as a “super enzyme,” Serrapeptase has been shown to have an effect on the movement of immune cells while the Protease blend works at normal cellular detoxification to efficiently digest all types of proteins. Pairing these enzymes with cofactor vitamins and minerals helps your body use the enzymes faster and more efficiently.
  • Easy Efficient Absorption: Formulated to be taken systemically, not digestively. It's best to take on an empty stomach, allowing enzymes to support your body rather than digest your food. Adults take 1 capsule, up to 2 times daily or as recommended by physician or healthcare professional. For best results, take on an empty stomach with a large glass of water, 30-60 minutes before or 2 hours after a meal.
  • For Most Lifestyles: MaryRuth's Serrapeptase Systemic Enzymes are Non-GMO & Vegan. Dairy Free, Nut Free, Gluten & Wheat Free, Soy Free, Nightshade Free, Sugar Free. This product CONTAINS Maltodextrin: which is corn-derived.
Bestseller No. 3

Pro-OneZyme Best Proteolytic Systemic Enzymes Supplement with Nattokinase & Seapose - 90 Capsules

  • UNIQUELY FORMULATED - ProOneZyme is the only supplement that contains 6 of the best quality proteolytic enzymes in one convenient vegan capsule. These ingredients include Bromelain, Nattokinase, Papain, Peptidase, Protease, Seaprose, Catalase and Rutin.
  • ALL NATURALLY MADE - Contains no wheat, yeast, soy or gluten. NO animal derivatives, sugars, artificial flavors, colors or fillers. It's perfect for vegetarians and meat lovers alike!
  • PERFORMANCE DRIVEN - Proteolytic Systemic Enzymes gives active enzymes the body can use. They can also work in part to help digest food. When the body is happy; you feel younger and full of life.
  • POWERFUL AND PROVEN - Nattokinase and Seaprose is gentle on the stomach. ProOneZyme Capsules are designed to withstand stomach acid and release inside the intestinal tract where it is absorbed and used in the body.
  • 100% RISK FREE GUARANTEE! If for any reason you are not satisfied with ProOneZyme simply return any unused portion for a full no hassle, 30-Day Money-Back Guarantee! Third Party Tested and manufactured in a GMP Facility.
SaleBestseller No. 4

Garden of Life Systemic Enzymes - FYI Restore for Muscle and Tissue Recovery for Women and Men, Vegan Enzyme Supplement, Bromelain, Protease, Papain, Vegan and Gluten Free, 60 Enteric Coated Capsules

  • MUSCLE & TISSUE RECOVERY: FYI Restore is the ultimate broad spectrum systemic enzyme formula; This high activity systemic enzymes formula works with the body's own processes to support normal tissue repair and recovery
  • MUSCLE SUPPLEMENT: This muscle repair supplement provides high levels of bromelain & papain to aid normal fibrin turnover and support healthy microcirculation in overused tissue; Systemic enzyme blend includes protease, nattokinase and serratiopeptidase
  • PROTEOLYTIC ACTIVITY: Contains a highly potent range of systemic enzymes, citrus and rutin bioflavonoids—plus alfalfa, algae and an ionic mineral blend with trace minerals, for healthy connective tissue integrity and turnover
  • ENTERIC-COATED VEGAN CAPSULES: Our muscle recovery supplement for men and women comes in capsules with algae based enteric coating to ensure the highly active systemic enzymes reach the small intestine for maximum effectiveness and targeted absorption
  • VEGAN SYSTEMIC ENZYME SUPPLEMENT: Our muscle and tissue recovery bromelain supplement is 100% Vegetarian and Vegan, Dairy Free, Gluten Free and Carbon Neutral
Bestseller No. 5

Vitälzym Original Proteolytic Systemic Digestive Enzyme Formula Serrapeptase Source | Anti-Inflammatory Immune and Joint Support Increase Blood Flow Cardio Function | Healthy Men Women (90 Capsules)

  • American Made, Essential for Health, Plant Based: Not All Complete Digestive System Enzyme Products Are Made The Same - Pay For True Quality & You Will Not Be Disappointed. World Nutrition is a pioneer of complementary systemic enzymes. In 2001 we introduced the original Vitalzym pill as a hybrid formula that offers both systemic & digestive benefits to provide total body support. It quickly became the best-selling systemic enzyme in the world and sold over $10M in the first 3 years alone
  • The Best Vegetarian Digestion Supplement & Remedy: Our Premium Strength Super Gut Defense Formula contains everything you need for full-body support: Protease, Serrapeptase, Papain, Bromelain, Amylase, Lipase, Rutin, & Amla. Each powerful ingredient is derived from natural, vegetarian sources. Most competitors use enzymes harvested from pigs & cows after slaughter. These enzymes are low-quality & strength, requiring a much higher dose as they’re less effective against targeted mediators
  • Advanced, Broad Spectrum Caps Promote Wellness: Our complex extract provides the optimal potency level of proteolytic enzymes that may assist with IBS, gas, inflammation, regulating your immune system, removing excess plaque & fibrin (fibrous tissue), & support the return of blood volume & flow. Vitälzym capsules are formulated to support health in the following systems: cognitive/mental, upper respiratory, cardiovascular, gastrointestinal, reproductive, joints, connective tissue, & skin
  • Fast Response, Organic, Calms Indigestion & Assists With IBS, Gas, Bloating: Regain bowel comfort with our perfect synergistic blend of systemic and digestive enzymes. It starts in the stomach & helps the body to break down food and absorb nutrients. After helping increase digestive abilities, the systemic enzymes take action in the bloodstream, moving throughout your entire body. This unique combination can help to improve your bodily processes and regain your quality of life
  • Formulated for Active Vitality Enhancement Plus Recovery: High-quality pure powder filled capsules that break down in your stomach provide digestive support with every dose. Some serrapeptase survives the acidic environment of the stomach and a dosage is released in the small intestine, allowing it to be absorbed into your bloodstream and distributed throughout your whole body. Our customers have reported increased energy, stamina, and recovery from intense exercise
Bestseller No. 6

Vitälzym Proteolytic Systemic Enzymes Liquid Gel Capsules with Serrapeptase, Anti-inflammatory Defense Treatment, Immune and Joint Support, Natural Ache Relief Plus Fertility Supplement (360 Capsules)

  • Enteric Coated Advanced Delivery Method: Vitalzym high potency gel caps are unlike any tablet or powder based enzyme product available on the market today. Our formula contains no gluten, yeast or dairy and is designed to ensure maximum absorption into the bloodstream where it is then dispersed via your circulatory system throughout your body
  • Ingredients: Vitalzym Extra Strength premium softgels are the original, all-natural, vegetarian multi enzyme complex. Vitalzym was designed using a scientific research process to identify nature’s miracle ingredients that include Serrapeptase, Bromelain, Papain, Rutin, Amylase, Protease, Lipase and Amla Extract
  • Protect Your Health: Living well in modern times can be stressful and a source of pain at times. Vitalzym contains the most effective, purified vegan-based enzyme blend to promote healing, repair human bodily functions and leave you feeling clear and fresh
  • Small, Easy To Swallow Gel Caps: Our advanced encapsulations deliver reliable results that offer pure, potent enzymes with reliable consistency and unrivaled absorption rates. Due to the highly effective delivery rate most people need a smaller dosage, and less doses per day
  • Made In Japan: Created by a team of international scientists, Vitalzym works best when combined with exercise, proper fluid intake, and a healthy diet. It is important to be mindful of all aspects of your health. When used properly, Vitalzym can greatly increase your cardio, lung, blood flow, and immune response as well as provide joint, circulatory system and inflammation support and much more
SaleBestseller No. 7

Garden of Life Joint Supplement for Men and Women - Wobenzym N Systemic Enzymes, Clinically Studied Formula for Healthy Joints, Mobility, Flexibility, Post-Exercise Recovery, Gluten Free, 200 Tablets

  • THE CLINICALLY STUDIED FORMULA: First introduced in Germany over 40 years ago, the Wobenzym N formula includes pancreatin protease, papain, bromelain, trypsin, chymotrypsin, rutoside trihydrate to help maintain healthy joints, mobility and flexibility
  • A TRADITION OF SUCCESS: Wobenzym N is a global leader in joint health and is the only systemic enzyme formula backed by decades of clinical research and customer satisfaction; Systemic enzymes work throughout the entire body to support overall joint health
  • HELPS IMPROVE JOINT COMFORT AND RANGE OF MOTION: Get going with Wobenzym N, the authentic systemic enzyme formula trusted by millions worldwide to provide clinically demonstrated support for joint & tendon health; For speedy recovery following exertion
  • GLUTEN FREE AND DAIRY FREE SYSTEMIC ENZYME FORMULA: A synergistic combination of plant-based enzymes, pancreatic enzymes & antioxidants—with Carica papaya and Sophora japonica; Temporary relief from aches, pains & muscle soreness due to everyday activity
  • FUEL YOUR HEALTH: Enzymes are essential biological catalysts involved in almost every single process in our bodies; Our powerful yet delicate enzymes are protected by a vegetable-based enteric coating for optimal absorption and utilization
Bestseller No. 8

Excellacor – Proteolytic Systemic Enzymes Formula – with Enteric-Coated Serrapeptase - Total Body Support - 90 Vegetarian Capsules - AST Enzymes

  • ADVANCED SYSTEMIC ENZYME FORMULA: a potent blend of enteric-coated Serrapeptase, proteases and herbs that synergistically support the body’s natural response to inflammation and joint function; used for more than a decade by thousands of people as a daily dietary supplement.*
  • RANGE OF USE: Supports the body’s natural response to inflammation including fatigued muscles and joint function, healthy blood circulation, and healthy fibrin metabolism.*
  • ACHIEVE OPTIMAL HEALTH: Elimination of potential waste substances from the body is a crucial step in metabolic processes for optimal health. Excellacor improves the body’s ability to rid of these wastes and restore normal balance.*
  • QUALITY ASSURED: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.
Bestseller No. 9

HCP Formulas - Fibrenza - Systemic Enzyme Complex with Fibrinolytic & Proteolytic Enzymes - Fibrin Defense, Inflammation & Cardiovascular Support - Vegetarian - Dietary Supplement - 60 Caps

  • FIBRENZA SUPPLEMENT: An advanced blend of 13 powerful systemic enzymes! HCP Formulas' Fibrenza is a natural systemic enzyme complex. Formulated with fibrinolytic & proteolytic enzymes, Fibrenza supports the body's ability to dissolve fibrin, maintain a healthy inflammatory response and cleanse the body of impurities for maximum body-wide benefits in a reliable, time-released capsule.
  • INFLAMMATION & CARDIOVASCULAR SUPPORT: Aging lowers your body's ability to produce sufficient levels of enzymes, often leading to inflammation and build-up of fibrin. Fibrenza harnesses potent systemic enzymes that break down proteins, toxins, and other cellular debris, such as Serrapeptase and Nattokinase—promoting powerful fibrin and anti-inflammatory defense essential for a healthy cardiovascular system.
  • ANTIOXIDANT: Not only are systemic enzymes powerful anti-inflammatory and anti-fibrin agents, but they also possess profound antioxidant properties. The foundation of anti-aging and detoxification protocols, Superoxide Dismutase helps break down potentially harmful oxygen molecules in cells that can cause tissue damage for better overall well-being.
  • SUPERIOR DELIVERY: Fibrenza utilizes a technologically advanced capsule without phthalates or chemicals. Unlike enteric coatings, AcidDefenz capsules use a non-GMO vegetable cellulose barrier to provide maximum protection against harsh stomach acids. They are time-released for more consistent enzyme absorption into the bloodstream every time.
  • PREMIUM INGREDIENTS: HCP Formulas specializes in ultra-premium nutraceutical supplements to better support your health. We source only the highest-grade Non-GMO ingredients that are vegetarian and free of gluten, dairy, wheat, yeast, and shellfish. Fibrenza contains NO Magnesium Stearate, Phthalates, Talc, or artificial colors or flavors and is proudly manufactured in the USA in GMP registered facilities.
Bestseller No. 10

Rootcology Systemic Enzymes (60 Capsules)

  • Systemic Enzymes is a combination of herbs, nutrients, and proteolytic enzymes that support modulation of the inflammatory response, the natural clearance of inflammatory proteins, and healthy lymphatic drainage.*
  • Contains herbs, nutrients and enzymes that may: Promote a normal inflammatory response. Help maintain healthy joints. Support the body’s antioxidant status. Support normal tissue repair post-operatively.*
  • The ingredients in Systemic Enzymes provide natural support for a healthy inflammatory response and help protect against oxidative stress.*
  • Cleaner, Smarter Supplements - Not all supplements are created equally. Rootcology products are made without gluten, dairy, pesticides and potentially harmful fillers. This product is non-GMO and vegetarian-friendly.*
  • Get to the Root - Rootcology is developed by clinical pharmacist Dr. Izabella Wentz. She is the bestselling author of two books promoting optimal thyroid health and getting to the 'Root' of your health journey.*
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